Letrozole for Fertility Everything You Need to Know
Long-term use of letrozole may negatively impact your bone density, which increases your risk of fractures. Letrozole is also used as a fertility treatment for women with polycystic ovary syndrome (PCOS), a hormonal imbalance that can disrupt the normal ovulation pattern. HR for the intent-to-treat (ITT) analysis of the monotherapy arms at 76 months (P value) is shown; the HR (HRCEN) for the censored analysis (with 95% confidence interval) is shown below the ITT value. Be careful if you drive or do anything that requires you to be alert.
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- Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
- If that happens, taking letrozole with food can help reduce the stomach upset it causes.
- Letrozole inhibits the aromatase activity by more than 99%, and endogenous estrogen synthesis by 97%-99% (12).
- In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified.
- There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
If these affect your jaw, it’s possible the pain could spread and feel like tooth pain. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.
The safety and effectiveness in pediatric patients have not been established. An interaction study (P017) with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics. No dosage adjustment is required for patients with renal impairment if creatinine clearance is greater than or equal to 10 mL/min see Clinical Pharmacology (12.3).
CLINICAL PHARMACOLOGY
There may be an increased risk of osteoporosis from taking letrozole. Letrozole might be used to help prevent breast cancer in certain high-risk post-menopausal women. Estrogen levels tend to be higher in women who drink alcohol than those who don’t. Since letrozole reduces estrogen levels, you may want to limit your alcohol consumption while taking it. In general, though, there aren’t any specific foods to avoid while taking letrozole, unless otherwise indicated by your healthcare provider. Some foods and supplements may tend to raise estrogen levels.
Drug Interactions for Femara
They can https://www.truccosposa.it/testo-depot-testosterone-enanthate-250-mg-omega-10/ suggest ways to help you manage a body weight that’s healthy for you. Additionally, you can find information about weight management here. If you’re concerned about gaining weight while taking letrozole, talk with your doctor. Don’t breastfeed during this treatment because the drug may come through into your breast milk. This is usually only slightly raised and you will have regular blood tests to check the levels.